"Shall I not inform you of the greatest of the major sins?" They said: "Of course O Messenger of Allah(s.a.w)!" He said: "Shirk with Allah disobeying parents, and false testimony." Or: "False speech" He said: "So the Messenger of Allah(s.a.w) would not stop saying it until we said ( to ourselves): 'I wish he would be quiet. "
Jami` at-Tirmidhi Book 35, Hadith 7