The Prophet forbade praying in the middle of the road, or defecating there, or urinating.
Sunan Ibn Majah Book 1, Hadith 64
← Previous Hadith "The Messenger of Allah said: 'Beware of stopping to rest and praying in the middle of the road, for it is the refuge of snakes and carnivorous animals, and beware of relieving yourselves in the middle of the road, for this is an act that provokes curses.'"

Sunan Ibn Majah Book 1, Hadith 63 Next Hadith → "Whenever the Prophet went to relieve himself, he would go far away."

Sunan Ibn Majah Book 1, Hadith 65